128 research outputs found
Ab initio study of the influence of nanoscale doping inhomogeneities in the phase separated state of LaCaMnO
The chemical influence in the phase separation phenomenon that occurs in
perovskite manganites is discussed by means of ab initio calculations.
Supercells have been used to simulate a phase separated state, that occurs at
Ca concentrations close to the localized to itinerant crossover. We have first
considered a model with two types of magnetic ordering coexisting within the
same compound. This is not stable. However, a non-isotropic distribution of
chemical dopants is found to be the ground state. This leads to regions in the
system with different effective concentrations, that would always accompany the
magnetic phase separation at the same nanometric scale, with hole-rich regions
being more ferromagnetic in character and hole-poor regions being in the
antiferromagnetic region of the phase diagram, as long as the system is close
to a phase crossover.Comment: 8 pages, 7 figures, 1 tabl
Occurrence of organotin compounds in waters of the spanish coast under the European Water Framework Directive
Organotin compounds (OTCs), such as tributyltin (TBT), are persistent organic pollutants that are
present in water samples (surface water, river water, sea water, waste water, etc.) because of
anthropogenic activities (antifouling agents in ship paints, biocides in polymers, etc.). The toxicity
and endocrine disruption potential of these chemicals have been demonstrated even at very low
levels (<1 ng L−1) (Devos et al. 2012). Due to the extensive presence of OTCs in all environmental
media as well as their adverse effects on human health and biota, quantitative and qualitative
determination of those com-pounds in complex environmental matrices has become a matter of
great concern, mainly butyl and phenyl-substituted. Also, these compounds are included in the list of
priority substances according to the EU Directive 2013/39/EU amending Directives 2000/60/EC and
2008/105/EC as regards priority substances in the field of water policy. This directive specifies
annual average environmental quality standard (AA-EQS) of 0.2 ng L−1 TBT and a maximum
allowable environmental quality standard (MAC-EQS) of 1.5 ng L−1 TBT for all surface waters.
Samples were collected in two semiconfined coastal areas, one of them an area with high industrial
and port activities (RÃa de Vigo) and the other one with high touristic and agricultural activity (Mar
Menor).The sampling campaigns were performed in spring and autumn of 2015. The levels of MBT,
DBT, TBT, MPhT, DPhT and TPhT in the seawater samples were analyzed by HS-SPME-GC–QqQMS/
MS method (Moscoso-Pérez et al. 2015).
MPhT, DPhT and TPhT were not detected in any sample at levels higher than LOQ. For butylated
compounds, MBT, DBT and TBT were detected in 100% of the analyzed samples in the Mar Menor.
In the Vigo estuary, MBT has been detected in 83.3% of the samples, the DBT in 75% and the TBT
in 88%. The TBT is present in 92% of the total of 39 analyzed samples, being detected in 100% of
the samples of the Mar Menor and in 88% of the samples of the RÃa de Vigo. These levels are
similar than those detected in other locations, and lower than the detected in ports near the coast of
Gijón characterized by a great maritime traffic (Centineo et al. 2004).Program of Consolidation and Structuring of Units of Competitive Investigation of the University System of Galicia (Xunta de Galicia) potentially cofinanced by ERDF in the frame of the operative Program of Galicia 2007-2013 (reference: GRC2013-047) and by the Ministry of Economy and Competitiveness (IMPACTA, project reference: CTM2013-48194-C3-2-R, and ARPA-ACUA, project reference: CTM2016-77945-C3-3-R)
Epidemiological Algorithm and Early Molecular Testing to Prevent COVID-19 Outbreaks in a Mexican Oncologic Center
Introduction: Prevention strategies and detection of latent COVID-19 infections in oncology staff and oncologic patients are essential to prevent outbreaks in a cancer center. In this study, we used two statistical predictive models in oncology staff and patients from the radiotherapy area to prevent outbreaks and detect COVID-19 cases.
Methods: Staff and patients answered a questionnaire (electronic and paper surveys, respectively) with clinical and epidemiological information. The data was collected through two online survey tools: Real-Time Tracking (R-Track) and Summary of Factors (S-Facts). According to the algorithm\u27s models, cut-off values were established. SARS-CoV-2 qRT-PCR tests confirmed the algorithm\u27s positive individuals.
Results: Oncology staff members (n=142) were tested, and 14% (n=20) were positives for the R-Track algorithm; 75% (n=15) were qRT-PCR positive. The S-Facts algorithm identified 7.75% (n=11) positive oncology staff members, and 81.82% (n=9) were qRT-PCR positive. Oncology patients (n=369) were evaluated, and 1.36% (n=5) were positive for the algorithms. The 5 patients (100%) were confirmed by qRT-PCR at a very early stage.
Conclusions: The proposed algorithms could prove to become an essential prevention tool in countries where qRT-PCR tests and vaccines are insufficient for the population
Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients
Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-matched cohort (n = 67) and compared patients with biopsy proven acute rejection (BPAR; 41%) to those without rejection (No-AR). We observed that CD3+ T cells, both CD8+ and CD4+, as well as CD19+ B cells were increased in patients with BPAR, particularly in biopsies performed in the early post-transplant period (<3 months). During this period immune subsets presented a good discriminative ability (CD4+ AUC 0.79; CD8+ AUC 0.80; B cells AUC 0.86; p < 0.05) and outperformed lipase (AUC 0.62; p = 0.12) for the diagnosis of acute rejection. We further evaluated whether this could be explained by differences in frequencies prior to transplantation. Patients presenting with early post-transplant rejection (<3 months) had a significant increase in T-cell frequencies pre-transplant, both CD4+ T cells and CD8+ T cells (p < 0.01), which were associated with a significant inferior rejection-free graft survival. T cell frequencies in peripheral blood correlated with pancreas acute rejection episodes, and variations prior to transplantation were associated with pancreas early acute rejection.Copyright © 2022 Rovira, Ramirez-Bajo, Bañón-Maneus, Hierro-Garcia, Lazo-Rodriguez, Piñeiro, Montagud-Marrahi, Cucchiari, Revuelta, Cuatrecasas, Campistol, Ricart, Diekmann, Garcia-Criado and Ventura-Aguiar
Grazers and fires: Their role in shaping the structure and functioning of the RÃo de la Plata Grasslands
Los Pastizales del RÃo de la Plata (PRP) son una de las áreas más extensas de ecosistemas abiertos (pastizales, arbustales y sabanas) del mundo. Históricamente, estos sistemas han experimentado, y lo siguen haciendo, una enorme pérdida de hábitats naturales. Más aun, en buena medida, su importancia ha sido invisibilizada frente a sistemas boscosos. El área remanente de ecosistemas abiertos (EA) varÃa según las fuentes del 38 al 58% del área original. Los EA son agroecosistemas particulares porque pueden combinar el suministro tanto de servicios ecosistémicos (SE) de provisión como de regulación y soporte. La maximización del suministro de SE en estos hábitats naturales depende, en parte, de comprender el papel de las dos principales perturbaciones que operan en ellos: el pastoreo y el fuego. Aunque estas dos perturbaciones son componentes naturales de los EA, son manipuladas por prácticas humanas. En este artÃculo revisamos el papel del pastoreo y el fuego en la estructura y el funcionamiento del PRP, partiendo de su papel durante el final del Pleistoceno y el Holoceno, y resumiendo evidencias de los efectos actuales del pastoreo y el fuego sobre la vegetación, la fauna y los procesos biogeoquÃmicos. Las evidencias muestran que los sistemas ganaderos en EA tienen, en dimensiones claves de la huella ambiental tales como la preservación de hábitats y la oferta de SE, el menor impacto entre las actividades agropecuarias. Los valores estimados de producción de carne equivalente en los EA representan una alta proporción de la producción total de la región, un volumen de producción capaz de cubrir el consumo de un 2.5% de la población mundial.The RÃo de la Plata Grasslands (RPG) are one of the largest areas of open ecosystems (grasslands, shrublands and savannas) in the world. Historically, these systems have experienced, and continue to experience, an enormous loss of natural habitats. Moreover, their importance has been largely invisible in comparison to forested systems. The remaining area of open ecosystems in the RPG region varies according to the source from 38 to 58% of the original area. Open Ecosystems (OE) are a special case of agroecosystems because they can combine the supply of both provisioning and regulating and supporting ecosystem services (ES). Preserving the provision of ES in these natural habitats depends, in part, on understanding the role of the two main disturbances operating in them: grazing and fire. Although these two disturbances are natural components of OE, both are manipulated by humans. In this paper we reviewed the role played by fire and grazing in the structure and functioning of the RPG starting from the late Pleistocene and Holocene, and summarizing current evidence on the effects of fire and grazing on vegetation, fauna and biogeochemical processes. The evidence indicates that among agricultural activities, direct grazing systems in OE have the lowest environmental footprint. At the same time are the key for habitat preservation and ES supply. Overall, the OE of the RPG still represent a high proportion of the area, are capable of covering 2.5% of the world’s population needs of high quality protein and, at the same time, guarding the regulation of key processes.Fil: Paruelo, José. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de AgronomÃa. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Oesterheld, Martin. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de AgronomÃa. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Altesor, Alice. Universidad de la Republica; UruguayFil: Piñeiro, Gervasio. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de AgronomÃa. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: RodrÃguez, Claudia. Universidad de la Republica; UruguayFil: Baldassini, Pablo. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de AgronomÃa. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Irisarri, Jorge Gonzalo Nicolás. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de AgronomÃa. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: López Mársico, Luis. Universidad de la Republica; UruguayFil: Pillar, Valério D.. Universidad de la Republica; Urugua
Experimental evaluation in wireless communications
This editorial sums up relevant topics on the assessment of wireless communication systems covered by the especial issue entitled "Experimental Evaluation in Wireless Communications". The topics include practical aspects on the implementation of distributed asynchronous non-linear kernel methods over wireless sensor networks; localization methods based on the exploitation of radio-frequency identification (RFID) wireless sensors and cellular networks or on sparsity approximations; channel sounding and assessment of broadband orthogonal frequency-division multiplexing (OFDM)-based wireless systems in high-speed vehicular communications; coexistence analysis of femtocell-based and outdoor-to-indoor systems; techniques for peak-to-average power ratio (PAPR) reduction; new solutions for baseband and radio frequency (RF) hardware impairments in full-duplex wireless systems; and, finally, suitability of interference alignment for broadband indoor wireless communications
Hard Two-Photon Contribution to Elastic Lepton-Proton Scattering: Determined by the OLYMPUS Experiment
The OLYMPUS collaboration reports on a precision measurement of the
positron-proton to electron-proton elastic cross section ratio, ,
a direct measure of the contribution of hard two-photon exchange to the elastic
cross section. In the OLYMPUS measurement, 2.01~GeV electron and positron beams
were directed through a hydrogen gas target internal to the DORIS storage ring
at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and
time-of-flight scintillators detected elastically scattered leptons in
coincidence with recoiling protons over a scattering angle range of to . The relative luminosity between the two beam species
was monitored using tracking telescopes of interleaved GEM and MWPC detectors
at , as well as symmetric M{\o}ller/Bhabha calorimeters at
. A total integrated luminosity of 4.5~fb was collected. In
the extraction of , radiative effects were taken into account
using a Monte Carlo generator to simulate the convolutions of internal
bremsstrahlung with experiment-specific conditions such as detector acceptance
and reconstruction efficiency. The resulting values of , presented
here for a wide range of virtual photon polarization ,
are smaller than some hadronic two-photon exchange calculations predict, but
are in reasonable agreement with a subtracted dispersion model and a
phenomenological fit to the form factor data.Comment: 5 pages, 3 figures, 2 table
What makes a task a problem in early childhood education?
This article begins with a theoretical discussion of the characteristics that a task should feature to be regarded as a mathematics problem suitable for pre-primary students. Those considerations are followed by a report of a classroom experience in which three problems involving quotative or partitive division were posed to pre-primary school pupils to determine the presence of otherwise of the respective characteristics. The findings show that the characteristics of pre-primary education problems depend on two factors: mathematical activity that engages pupils and a structure that favours both their understanding of the problem and the application and verification of the solutions
Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas
<p>Abstract</p> <p>Background</p> <p>Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate the utility of the sCD26 as a biomarker for CRC and advanced adenomas in a high-risk group of patients. The relationship of this molecule with polyp characteristics was also addressed.</p> <p>Methods</p> <p>sCD26 levels were measured by ELISA in 299 symptomatic and asymptomatic patients who had undergone a colonoscopy. Patients were diagnosed as having no colorectal pathology, non-inflammatory or inflammatory bowel disease, polyps (hyperplastic, non-advanced and advanced adenomas) or CRC.</p> <p>Results</p> <p>At a 460 ng/mL cut-off, the sCD26 has a sensitivity and specificity of 81.8% (95% CI, 64.5-93.0%) and 72.3% (95% CI, 65.0-77.2%) for CRC regarding no or benign colorectal pathology. Clinicopathological analysis of polyps showed a relationship between the sCD26 and the grade of dysplasia and the presence of advanced adenomas. Hence, a 58.0% (95% CI, 46.5-68.9%) sensitivity detecting CRC and advanced adenomas was obtained, with a specificity of 75.5% (95% CI, 68.5-81.0%).</p> <p>Conclusions</p> <p>Our preliminary results show that measurement of the sCD26 is a non-invasive and reasonably sensitive assay, which could be combined with others such as the faecal occult blood test for the early diagnosis and screening of CRC and advanced adenomas. Additional comparative studies in average-risk populations are necessary.</p
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